Team 1 - Gisèle Bonne
Genetics and Pathophysiology of Neuromuscular Disorders
Team leader: Gisèle Bonne
The team’s project focuses on 4 groups of disease affecting the skeletal and cardiac muscles: the myopathies linked collagen type VI, the centronuclear myopathies, the Emery-Dreifuss muscular dystrophies and other striated muscle laminopathies and the familial hypertrophic cardiomyopathies. A complementary research theme is the study of the mechanisms of contractile dysfunction, characteristic common to these diseases
The team’s project revolves around three major axes: i) definition of genetic and clinical spectrum and natural history of these disorders; ii) investigation the pathogenic mechanisms of gene mutations that induce these cardiac and/or skeletal muscle affections with the overall goal to iii) identify and test therapeutic avenues for these disorders.
The team’s project focuses on 4 groups of disease affecting the skeletal and cardiac muscles: the myopathies linked collagen type VI, the centronuclear myopathies, the Emery-Dreifuss muscular dystrophies and other striated muscle laminopathies and the familial hypertrophic cardiomyopathies. A complementary research theme is the study of the mechanisms of contractile dysfunction, characteristic common to these diseases
The team’s project revolves around three major axes: i) definition of genetic and clinical spectrum and natural history of these disorders; ii) investigation the pathogenic mechanisms of gene mutations that induce these cardiac and/or skeletal muscle affections with the overall goal to iii) identify and test therapeutic avenues for these disorders.
Team 1 is composed of:
| • V. Allamand, CR1, Inserm • R. Ben Yaou, ARC, AIM • A. Bertrand, Post-doc • M. Beuvin, IE, AIM • M. Bitoun, CR1, Inserm • G. Bonne, DR2, Inserm • L. Briñas, Post-doc • P. Castets, Post-doc • ME. Cattin, PhD Student • K. Chikhaoui, IE • S. Chiron, Post-doc • C. Coirault, CR1, Inserm • D. Duboc, PU-PH • AC. Durieux, Post-doc • C. Gartioux, TR, AIM | • L. Gueneau, Post-doc • J. Laine, CR • I. Nelson, IR • A. Papadopoulos, IE • B. Prudhon, TR, AIM • S. Quijano-Roy, PH, AP • L. Ramanoudjame, IE • NB. Romero, PH, AP • T. Stojkovic, PH, AP • S. Varnous, PH, AP • S. Vassilopoulos, Post-doc • N. Vignier, IR, AIM • T. Voit, HU PPH |
This team hosts Lucie Carrier's team established in Hamburg, working on functional genomics of familial hypertrophic cardiomyopathy, composed by:
• V. Behrens, Post-doc HH
• L. Carrier, DR2, CNRS
• F.W. Friedrich, Post-doc, HH
• C. Gedicke, PhD Student, HH
• D. Khajetoorians, PhD student HH
• E. Kraemer, TR, HH
• S. Maron, Medical doctoral student, HH
• G. Mearini, Post-doc, HH
• A. Porto, Medical doctoral student, HH
• S. Reischmann, TR, HH
• S. Schlossarek, Post-doc, HH
• S. Schuermann, Medical doctoral student, HH
• A. Schwalm, Student, HH
• T. Thottakara, Student, HH
Their collaborators are the different teams of the following networks:
• French Network "EDMD & other nuclear envelope diseases" Coordinator G Bonne / F. Leturcq.
• European Consortium “Euro-Laminopathies” (FP6) Coordinator R Foisner (Austria)
• European Network “NMD-Chip” (FP7) Coordinator N Levy (France)
• European Network “TREAT-NMD” (FP7) Coordinator K Bushby (UK)
• Transatlantic research network "Cardiac progenitors: roles in development and cardiovascular disease" (Leducq Foundation) Coordinators P Ménasché (Europe) / K Chien (USA), Principal Investigator L Carrier, Associated member G Bonne.
• European Network “Euro-Progeria”. Coordinator N Levy (France)
• European Netwok, EU-FP7-Health-BIG-Heart. Coordinator C Redwood, Prinicpal Investigator L Carrier. Patners Oxford, Londres, Florence, Amsterdam.
• German Network DFG-FOR-604 « Signalling pathways in the healthy and diseased heart ». Coordinator T Eschenhagen. Principal Investigator L Carrier. Five other teams from the University Medical Center Hamburg-Eppendorf.
• European Consortium “Euro-Laminopathies” (FP6) Coordinator R Foisner (Austria)
• European Network “NMD-Chip” (FP7) Coordinator N Levy (France)
• European Network “TREAT-NMD” (FP7) Coordinator K Bushby (UK)
• Transatlantic research network "Cardiac progenitors: roles in development and cardiovascular disease" (Leducq Foundation) Coordinators P Ménasché (Europe) / K Chien (USA), Principal Investigator L Carrier, Associated member G Bonne.
• European Network “Euro-Progeria”. Coordinator N Levy (France)
• European Netwok, EU-FP7-Health-BIG-Heart. Coordinator C Redwood, Prinicpal Investigator L Carrier. Patners Oxford, Londres, Florence, Amsterdam.
• German Network DFG-FOR-604 « Signalling pathways in the healthy and diseased heart ». Coordinator T Eschenhagen. Principal Investigator L Carrier. Five other teams from the University Medical Center Hamburg-Eppendorf.
Update: April 2010
